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  • P-ISSN2233-4203
  • E-ISSN2093-8950

Global Histidine Phosphoproteomics in Human Prostate Cancer Cells

Mass Spectrometry Letters, (P)2233-4203; (E)2093-8950
2020, v.11 no.3, pp.52-58
https://doi.org/10.5478/MSL.2020.11.3.52
Yan Gao (Kyungpook National University)
Doeun Kim (Kyungpook National University)
Eunji Sung (Kyungpook National University)
Minjia Tan (Kyungpook National University)
Tae Gyun Kwon (Kyungpook National University)
Jun Nyung Lee (Kyungpook National University)
Sangkyu Lee (Kyungpook National University)

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Abstract

Histidine phosphorylation (pHis) is increasingly recognized as an important post translational modification (PTM) in regulating cellular functions in eukaryotes. In order to clarify the role of pHis in mammalian cell signaling system, a global phos-phorylation study was performed in human prostate cancer cells, PC-3M, using a TiO 2 affinity chromatography. A total number of 307 pHis sites were identified on the 268 proteins among total identified 9,924 phosphorylation sites on 3,316 proteins. In addition, 22 pHis proteins were classified in enzyme category. This report provides the first database for the study of pHis in prostate cancer cells.

Submission Date
2020-07-18
Revised Date
2020-09-03
Accepted Date
2020-09-03

Mass Spectrometry Letters