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  • P-ISSN2233-4203
  • E-ISSN2093-8950

Comparison of Matrices for Optimal Analysis of Synthetic Polymers Using MALDI-TOF Mass Spectrometry

Mass Spectrometry Letters, (P)2233-4203; (E)2093-8950
2020, v.11 no.4, pp.78-81
https://doi.org/10.5478/MSL.2020.11.4.77
Hee-Jin Yoo (Korea Basic Science Institute (KBSI))
Duck-Hyun Kim (Korea Basic Science Institute (KBSI))
Yoon-Ji Choi (Korea Basic Science Institute (KBSI))
Jung Hoon Choi (Korea Basic Science Institute (KBSI))
Moonhee Park (Korea Basic Science Institute (KBSI))
DongJin Shin (Korea Basic Science Institute (KBSI))
YoonSeok Oh (Korea Basic Science Institute (KBSI))
YangSun Kim (Korea Basic Science Institute (KBSI))
Kun Cho (Korea Basic Science Institute (KBSI))

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Abstract

Characterization of the various chemical aspects of composite polymers is important for quality control of manufac-tured polymers. In this study, we compared three suitable matrices (α cyano-4-hydroxycinnamic acid [CHCA], 2,5 dihydroxy benzoic acid [2,5-DHB], and dithranol), to characterize various synthetic polymers by matrix-assisted laser desorption/ioniza-tion time-of-flight mass spectrometry. Although the spectra obtained with the CHCA and 2,5-DHB matrices were generally good, in certain samples ghost peaks disappeared only when dithranol was used as the matrix. Furthermore, we examined the use of sodium trifluoroacetate (NaTFA) as an additive to reduce interference by metals and copolymers in the spectra. In conclusion, appropriate selection of a matrix, according to the characteristics of the polymer, and the use of additives to improve sensitivity are important considerations for polymer analysis and development.

keywords
MALDI-TOF MS synthetic polymer CHCA 2 5-DHB dithranol
Submission Date
2020-09-23
Revised Date
2020-10-22
Accepted Date
2020-10-22

Mass Spectrometry Letters