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  • P-ISSN2233-4203
  • E-ISSN2093-8950

Determination of Nitarsone in Pork, Egg, Milk, Halibut, Shrimp, and Eel Using QuEChERS and LC-MRM

Mass Spectrometry Letters, (P)2233-4203; (E)2093-8950
2021, v.12 no.1, pp.11-15
https://doi.org/10.5478/MSL.2021.12.1.11
Jin Hee Kim (College of Pharmacy, Dankook University)
Yong Jin Jang (College of Pharmacy, Dankook University)
Dong Yoon Kim (College of Pharmacy, Dankook University)
Hyo Chun Lee (College of Pharmacy, Dankook University)
Yong Seok Choi (College of Pharmacy, Dankook University)

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Abstract

Nitarsone is an organoarsenic antiprotozoal drug widely used to treat blackhead disease in turkeys and chickens. However, since its biological conversion into inorganic arsenic, a carcinogen was known, its residue in foods should be regu-lated. Thus, here, a novel method to determine residual nitarsone in various food commodities (pork, milk, egg, halibut, eel, and shrimp) using QuEChERS and LC-MRM was developed. The developed method was successfully validated through specificity, linearity (coefficient of determination, at least 0.991), recovery (R, 63.6 - 85.6%), precision (the relative standard deviation of R, 0.5 - 10.6%), and sensitivity (the lower limit of quantitation, 5 ppb) by following the Ministry of food and drug safety (MFDS) guidelines. The present method is the first mean to quantitate nitarsone using LC-MRM, and it was designed to be conveniently merged into a new method to quantitate multiple veterinary drugs for the positive list system (PLS). Therefore, the present method could contribute to fortify the food safety system in South Korea.

keywords
nitarsone food QuEChERS MRM PLS
Submission Date
2021-02-12
Revised Date
2021-03-09
Accepted Date
2021-03-09

Mass Spectrometry Letters