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  • P-ISSN2233-4203
  • E-ISSN2093-8950

Correlation between the Content and Pharmacokinetics of Ginsenosides from Four Different Preparation of Panax Ginseng C.A. Meyer in Rats

Mass Spectrometry Letters, (P)2233-4203; (E)2093-8950
2021, v.12 no.1, pp.16-20
https://doi.org/10.5478/MSL.2021.12.1.16
Ji-Hyeon Jeon (College of Pharmacy, Kyungpook National University)
Jaehyeok Lee (College of Pharmacy, Kyungpook National University)
Chul Haeng Lee (College of Pharmacy, Dankook University)
Min-Koo Choi (College of Pharmacy, Dankook University)
Im-Sook Song (College of Pharmacy, Kyungpook National University)

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Abstract

We aimed to compare the content of ginsenosides and the pharmacokinetics after the oral administration of four dif-ferent ginseng products at a dose of 1 g/kg in rats. The four different ginseng products were fresh ginseng extract, red ginseng extract, white ginseng extract, and saponin enriched white ginseng extract prepared from the radix of Panax ginseng C.A. Meyer. The ginsenoside concentrations in the ginseng product and the rat plasma samples were determined using a liquid chromatogra-phy-tandem mass spectrometry (LC-MS/MS). Eight or nine ginsenosides of the 15 tested ginsenosides were detected; however, the content and total ginsenosides varied depending on the preparation method. Moreover, the content of triglycosylated ginse- nosides was higher than that of diglycosylated ginsenosides, and deglycosylated ginsenosides were not present in any prepara-tion. After the single oral administrations of four different ginseng products in rats, only four ginsenosides, such as 20(S)-ginsenosides Rb1 (GRb1), GRb2, GRc, and GRd, were detected in the rat plasma samples among the 15 ginsenosides tested. The plasma concentrations of GRb1, GRb2, GRc, and GRd were different depends on the preparation method but pharmacoki-netic features of the four ginseng products were similar. In conclusion, a good correlation between the area under the concentra-tion curve and the content of GRb1, GRb2, and GRc, but not GRd, in the ginseng products was identified and it might be the result of their higher content and intestinal biotransformation of the ginseng product.

Submission Date
2021-02-25
Revised Date
2021-03-17
Accepted Date
2021-03-22

Mass Spectrometry Letters