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- E-ISSN 2093-8950
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- P-ISSN2233-4203
- E-ISSN2093-8950
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Evaluation of Metabolic Stability of Kinsenoside, an Antidiabetic Candidate, in Rat and Human Liver Microsomes
Mass Spectrometry Letters / Mass Spectrometry Letters, (P)2233-4203; (E)2093-8950
2015, v.6 no.2, pp.48-51
https://doi.org/10.5478/MSL.2015.6.2.48
(Hanyang University)
(Hanyang University)
(Hanyang University)
(Huazhong University)
(Huazhong University)
(Huazhong University)
(Kunming Institute of Botany)
(Hanyang University)
(Hanyang University)
(Hanyang University)
(Huazhong University)
(Huazhong University)
(Huazhong University)
(Kunming Institute of Botany)
(Hanyang University)
Rehman,
S. U., Kim,
I. S., Choi,
M. S., Luo,
Z., Yao,
G., Zhang,
Y., Xue,
Y. B., &
Yoo,
H.
H.
(2015). Evaluation of Metabolic Stability of Kinsenoside, an Antidiabetic Candidate, in Rat and Human Liver Microsomes. Mass Spectrometry Letters, 6(2), 48-51, https://doi.org/10.5478/MSL.2015.6.2.48
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Abstract
Kinsenoside is a principle bioactive compound of Anoectochilus formosanus. It exhibits various pharmacological effects such as antihyperglycemic, antioxidant, anti-inflammatory, immunostimulating, and hepatoprotective activities and has recently been developed as an antidiabetic drug candidate. In this study, as part of an in vitro pharmacokinetic study, the stability of kinsenoside in rat and human liver microsomes was evaluated. Kinsenoside was found to have good metabolic stability in both rat and human liver microsomes. These results will provide useful information for further in vivo pharmacokinetic and metabolism studies.
- keywords
- kinsenoside, stability, liver microsomes
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- Submission Date
- 2015-05-08
- Revised Date
- 2015-05-28
- Accepted Date
- 2015-06-01
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