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- E-ISSN 2093-8950
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- E-ISSN2093-8950
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Development of an Isotope Dilution Mass Spectrometry (IDMS)-Based Method for the Analysis of Ibuprofen
Mass Spectrometry Letters / Mass Spectrometry Letters, (P)2233-4203; (E)2093-8950
2017, v.8 no.3, pp.49-52
https://doi.org/10.5478/MSL.2017.8.3.49
(Korea Research Institute of Standard and Science)
(Korea Research Institute of Standard and Science)
(Korea Research Institute of Standard and Science)
Lee,
J., &
Kim,
B.
(2017). Development of an Isotope Dilution Mass Spectrometry (IDMS)-Based Method for the Analysis of Ibuprofen. Mass Spectrometry Letters, 8(3), 49-52, https://doi.org/10.5478/MSL.2017.8.3.49
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Abstract
Ibuprofen is one of the most popular analgesic and antipyretic drugs. An isotope dilution mass spectrometry method based on LC/MS was developed as a candidate reference method for the accurate determination of ibuprofen in pharmaceutical tablets. Isotope labelled ibuprofen, ibuprofen-d 3 , was added as an internal standard into sample extracts. Ibuprofen and ibupro-fen-d 3 , was analysed by LC/MS in a selected ion monitoring (SIM) mode to detect ions at m/z 205 and 208, respectively. The repeatability and reproducibility of the developed ID-LC/MS method were tested for the validation and assessment of metrolog-ical quality of the method.
- keywords
- Ibuprofen, ID-LC/MS, Method Validation, Pharmaceuticals
Reference
1
Huidobro, A. L. (2006). . J. Chromatogr. A, 1119, 238-.
2
Gasco-Lopez, A. I. (1999). . Pharm. Biomed. Anal, 21, 143-.
3
Sun, Y. (2003). . J. Pharm. Biomed. Anal, 30, 1611-.
4
Whelan, M. R. (2002). . J. Pharm. Biomed. Anal, 30, 1355-.
5
Tsikas, D. (2017). . J. Chromatogr. B, 1043, 158-.
6
Stubberud, K. P. (1998). . J. Chromatogr. A, 826, 92-.
7
Hamoudová, R. (2006). . J. Pharm. Biomed. Anal, 41, 1463-.
8
Palabiyik, İ. M. (2004). . J. Pharm. Biomed. Anal, 34, 473-.
9
Alnouti, Y. (2005). . J. Chromatogr. A, 1080, 99-.
10
Wu, J. (2010). . J. Chromatogr. A, 1217, 1471-.
11
Quinn, T. (1997). . J. Metrologia, 34, 61-.
12
Lee, J. (2013). . Anal. Chim. Acta, 787, 132-.
13
Shin, H. (2013). . Food Chem, 138, 1109-.
14
Lee, J. (2016). . J. Food Compos. Anal, 50, 49-.
15
Hyunju Shin. (2010). Development of an Isotope-Dilution Liquid Chromatography/Mass Spectrometric Method for the Accurate Determination of Acetaminophen in Tablets. Bulletin of the Korean Chemical Society, 31(12), 3663-3667.
- Submission Date
- 2017-07-25
- Revised Date
- 2017-09-11
- Accepted Date
- 2017-09-11
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