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- E-ISSN 2093-8950
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- P-ISSN2233-4203
- E-ISSN2093-8950
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Simultaneous Quantification of 13 Ginsenosides by LC-MS/MS and its Application in Diverse Ginseng Extracts
Mass Spectrometry Letters / Mass Spectrometry Letters, (P)2233-4203; (E)2093-8950
2018, v.9 no.2, pp.41-45
https://doi.org/10.5478/MSL.2018.9.2.41
(Kyungpook National University)
(Kyungpook National University)
(Kyungpook National University)
(Kyungpook National University)
(Kyungpook National University)
Jo,
J. J., Cho,
P. J., &
Lee,
S.
(2018). Simultaneous Quantification of 13 Ginsenosides by LC-MS/MS and its Application in Diverse Ginseng Extracts. Mass Spectrometry Letters, 9(2), 41-45, https://doi.org/10.5478/MSL.2018.9.2.41
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Abstract
Ginseng (Panax ginseng Meyer) has been used as traditional herbal drug in Asian countries. Ginsenosides are major components having pharmacological and biological efficacy like anti-inflammatory, anti-diabetic and anti-tumor effects. To con- trol the quality of the components in diverse ginseng products, we developed a new quantitative method using LC-MS/MS for 13 ginsenosides; Rb1, Rb2, Rc, Rd, Re, Rf, 20(S)-Rh1, 20(S)-Rh2, Rg1, 20(S)-Rg3, F1, F2, and compound K. This method was successfully validated for linearity, precision, and accuracy. This quantification method applied in four representative ginseng products; fresh ginseng powder, white ginseng powder, red ginseng extract powder, and red ginseng extract. Here the amounts of the 13 ginsenosides in the various type of ginseng samples could be analyzed simultaneously and expected to be suitable for quality control of ginseng products.
- keywords
- LC-MS/MS, ginsenoside, fresh ginseng, white ginseng, red ginseng
Reference
1
BAE,EUN-AH. (2003). Transformation of Ginsenosides to Compound K (IH-901) by Lactic Acid Bacteria of Human Intestine. Journal of Microbiology and Biotechnology, 13(1), 9-14.
2
3
인준교. (2006). 고려인삼의 간이법에 의한 홍삼제조 및 사포닌 상분분석. 한국자원식물학회지, 19(1), 133-20.
4
5
Fuzzati, N.. (2004). . J. Chromatogr. B, 812, 119-. http://dx.doi.org/10.1016/S1570-0232(04)00645-2.
6
Kwon, S. W.. (2001). . J. Chromatogr. A, 921, 335-. http://dx.doi.org/10.1016/S0021-9673(01)00869-X.
7
8
최재을. (2010). 인삼의 가공방법에 따른 일반성분 및 Ginsenoside 함량 변화. 한국약용작물학회지, 18(2), 118-125.
9
이상명. (2015). Characterization of Korean Red Ginseng (Panax ginseng Meyer): History, preparation method, and chemical composition. Journal of Ginseng Research, 39(4), 384-391.
10
Brion Research Institute. Exploration of Ginseng Plantation and Processing. http://www.suntenglobal.com/news/img/QNSpring09.pdf.
11
Gyo In. (2012). New Method for Simultaneous Quantifi cation of 12 Ginsenosides in Red Ginseng Powder and Extract: In-house Method Validation. Journal of Ginseng Research, 36(2), 205-210. http://dx.doi.org/10.5142/jgr.2012.36.2.205.
12
Kim, S. N.. (2007). . J. Pharm. Biomed. Anal., 45, 164-. http://dx.doi.org/10.1016/j.jpba.2007.05.001.
- Submission Date
- 2017-12-29
- Revised Date
- 2018-03-12
- Accepted Date
- 2018-03-12
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